Real World Evidence (RWE) requires the correlation of complex, frequently changing, unstructured data. To the enterprise architect, that means extracting value from data that doesn't neatly fit solutions. In this white paper, we dive into the details of why relational databases are ill-suited to handle the massive volumes of disparate, varied, and changing data that is required to be successful with RWE. It is for this reason that leading life science organizations are going beyond relational to embrace new kinds of databases. And when they do, the results can be dramatic.